Randolph Nesse Photo

Randolph M. Nesse, M.D.


Insights from the Frontier of Evolutionary Psychiatry

This book explains why natural selection can't eliminate mental disorders...and how evolutionary biology can provide psychiatry with the scientific foundation that has been missing.

One of The Economist's Books of the Year for 2019

“This book sets out to show how evolution underpins (or should underpin) psychiatry. In doing so, it will surely change the face of medicine -- and deservedly so.” —Robin Dunbar

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Simplify Podcast about why painful emotions persist, 2019

Video of a Nov 2019 talk on why disease genes persist

Nesse & Schulkin: An evolutionary medicine perspective on pain and its disorders. PhilTransRS B, 2019

Nesse: Core Principles for Evolutionary Medicine, 2019

Nesse & Natterson-Horowitz: Evolutionary Medicine, a great way to teach biology, 2019

Nesse, Stein: How evolutionary psychiatry can advance psychopharmacology, 2019

Nesse, Dawkins: Evolutionary Medicine chapter in Oxford Textbook of Medicine, 2019

Tinbergen's Four Questions, EMPH, 2019

The Smoke Detector Principle, EMPH, 2019

Grunspan, et al., Core Concepts of Evolutionary Medicine, 2017

Evolutionary foundations for psychiatric research and practice, 2017

Nesse Anorexia: A Perverse Effect of Trying to Control the Starvation Response BBS 2017

Nesse, Finch, Nunn: Evolution, Sleep, & Alzheimer's Disease, 2017

Five Evolutionary Principles for Understanding Cancer, 2017

Thomas, Nesse, et al. Evolutionary Ecology of Organs, Trends in Cancer, 2016

Social selection is a powerful explanation for prosociality. BBS, 2016

Evolution and Stress, 2016

Hauser, Nesse, Schwarz: Lay Theories of Health and Illness, 2016

Fried & Nesse: Depression sum scores don't add up. BMC Med 2015

Evolutionary psychology and mental health. 2015

Will computers ever evolve to be as wonderful as dogs?

How Stupid Not to Have Thought of That!

A general ''Theory of Emotion'' is neither necessary nor possible, Emotion Review, 2014

Fried & Nesse: Depression is more than the sum of its parts, Psy Med, 2013

Aktipis & Nesse: Evolutionary foundations for cancer biology, Evolutionary Applications, 2013.

Nesse, et al. Evolutionary Molecular Medicine, J Mol Medicine, 2012

Nesse & Stein: Towards a genuinely medical model for psychiatric nosology, BMC Medicine, 2012

Antolin, et al. Evolution and medicine in undergraduate education: A prescription for all biology students, Evolution, 2012

Natural selection is simple, but the systems It shapes are unimaginably complex, EDGE, 2012

Evolution: A basic science for medicine, 2012

Nesse & Jackson: Evolutionary foundations for psychiatric diagnosis, 2011

Ten questions for evolutionary studies of disease vulnerability, Evol Apps, 2011

Why has natural selection left us so vulnerable to anxiety and mood disorders? Can J Psychiatry, 2011

Nesse & Foxman: Evolution of sexually transmitted diseases, NYAS, 2011

Nesse & Dawkins: Evolutionary medicine chapter in Oxford Textbook of Medicine, 2010

Evolutionary perspectives in health and medicine, PNAS, 2010

Social selection and the origins of culture, 2010

Book: Why We Get Sick
Book: Evolution and Commitment