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The core idea of evolutionary medicine is simple enough. Analyze traits that leave organisms vulnerable to disease to try to understand why natural selection did not do better. But to actually do this turns out to be very difficult. Few of the problems are technical, most are conceptual. It is very hard for people to recognize that diseases themselves do not have evolutionary explanations, and harder yet for them to systematically list all possible explanations and the evidence for and against each one. After years of trying to help students get this all straight, I wrote the "Ten Questions" paper to be as close to a Betty Crocker recipe for aspiring evolutionary medicine researchers as I could. Some have told me it helps. For a different, more negative version that lists common errors, see the Table in my chapter in the Trevathan volume.

Nesse RM. Ten questions for evolutionary studies of disease vulnerability. Evolutionary Applications;4(2):264-77, 2011.